α1-MG抗原

货号：G7023

简介：
α1-microglobulin (A1M), also called protein HC, a plasma and tissue protein with antioxidative properties, was first discovered in human urine about 40 years ago . It has a mass of 26 kDa, consists of 183 amino acid residues, and has been identified in a wide range of other species . A1M is a member of the lipocalin family of structurally related proteins in bacteria, plants and animals. The recently published crystal structure shows that the protein consists of an eight-stranded, anti-parallel β-barrel with a highly conserved cysteine residue in position 34 located in a loop near the open top of the beta-barrel The lipocalin pocket inside the β-barrel serves as a ligand-binding entity in many of the lipocalins. A1M is synthesized and secreted from liver and most other epithelial cells, and present in blood and all tissues at remarkably constant concentrations, 1–2 μM . The protein is found in blood and tissues both in free form and bound to immunoglobulin A, albumin or prothrombin