重组凝血因子XIIIa

货号：F7076

简介：
FXIIIa belongs to the family of human transglutaminases (TG).This group of enzymes is defined by their common ability to catalyze thiol- and Ca2+-dependent transamidation reactions. The TG-catalyzed reaction between specific Gln and Lys residues within substrate proteins results in the formation of covalent cross-links, defined as ϵ-(γ-glutamyl)lysine isopeptide bonds. The major physiological function of FXIIIa is to stabilize the fibrin clot during coagulation. FXIIIa cross-links α- and γ-chains of fibrin monomers within fibrin fibers once they have been formed. The intermolecular cross-linking of the fibrin monomers converts loose fibrin fibers into a stable fiber network that is able to withstand mechanical stress and resist clot rupture . FXIIIa deficiency, which causes severe bleeding diathesis, demonstrates the essential role of FXIIIa in coagulation.