神经丝轻链NFL抗体

货号：grN124

简介：
Neurofilament-light chain (Nf-L) is a reliable biomarker in the context of neurodegenerative diseases (NDD) and traumatic brain injuries (TBI). This protein is found principally in large-caliber myelinated axons and is part of a complex called neurofilament (Nf). Nf-L is associated with other intermediate filaments (IF) subunits: neurofilament-heavy chain (Nf-H), medium chain (Nf-M) and alpha-internexin in the central nervous system (CNS) or peripherin in the peripheral nervous system (PNS) . They are in general composed of three domains: the head, the rod and the tail. Parts of the rod domain are relatively conserved among the IF as it is essential to enhance the polymerization of the Nf. Once assembled, Nfs are located mainly in the axons and organized as a network where they are essential to maintain the axon caliber, to ensure the radial growth and the transmission of electrical impulses. Under physiological conditions, low amounts of Nf-L are released during brain development, maturation and aging. However, when axonal damages or neuronal degeneration occur, it is released in larger quantities into the brain interstitial fluid, cerebrospinal fluid (CSF) and blood.